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HPV-Related Papillary Lesions of the Oral Mucosa: A Review

  • Special Issue: Colors and Textures, a Review of Oral Mucosal Entities
  • Published:
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Abstract

Human papillomaviruses (HPVs) are causative of a group of clinically papillary lesions. The HPV-related lesions of the oral cavity include squamous papilloma, condyloma acuminatum, verruca vulgaris, and multifocal epithelial hyperplasia. Benign entities, such as verruciform xanthoma or giant cell fibroma, as well as malignancies, such as papillary squamous cell carcinoma and verrucous carcinoma, may be considered in the clinical and/or histologic differential diagnoses of these lesions. Mechanisms of infection, epidemiology, clinical presentations, histologic features, and differential diagnoses of the HPV-related oral pathologies are discussed. Current concepts of viral transmission, especially as pertaining to lesions in pediatric patients, and the impacts of HPV vaccination are reviewed.

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Photograph courtesy of Dr. Duane Schafer

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Photograph courtesy of Dr. Brenda Nelson

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  1. Division of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA

    Sasha J. Betz

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Betz, S.J. HPV-Related Papillary Lesions of the Oral Mucosa: A Review. Head and Neck Pathol 13, 80–90 (2019). https://doi.org/10.1007/s12105-019-01003-7

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  • DOI: https://doi.org/10.1007/s12105-019-01003-7

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